Detailed information
Composition:
Each tablet contains 120 mg Fexofenadine hydrochloride.
Each tablet contains 180 mg Fexofenadine hydrochloride.
Properties:
Fexofenadine, an active metabolite of terfenadine, is a non-sedating antihistamine; it doesn't possess significant sedative or antimuscarinic actions.
Pharmacokinetics:
Fexofenadine is rapidly absorbed after oral administration with peak plasma concentrations being reached in 2-3 hours. About 5% of total dose is metabolized mostly by the intestinal mucosa with only 0.5 to 1.5% of dose undergoing hepatic biotransformation and elimination half-life of about 14 hours. Fexofenadine excretion is mainly in the faeces with only 10% being present in the urine and it doesn't appear to cross the blood-brain barrier.
Indications:
Fexofenadine is indicated for the relief of symptoms associated with seasonal allergic rhinitis such as rhino'rrhoea, itchy nose, red eyes and urticaria.
Contraindications:
Patients with known hypersensitivity to the drug.
Side Effect:
It may cause nausea, dyspepsia, fatigue, palpitations.
Precautions:
Fexofenadina should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when Fexofenadine is used to a nursing woman.
Fexofenadine should be used with caution in patients with renal impairment.
Drug Interactions:
Antacids containing aluminum and magnesium hydroxide have reduced the absorption of Fexofenadine,
Plasma concentrations of Fexofenadine are increased after the concomitant administration of erythromydn or Ketoconazole.
Dosage and Administration:
120mg or 180mg daily as a single dose.
Presentation:
Boxes of 20 tablets 120mg.
Boxes of 20 tablets 180mg. |
