Detailed information
COMPOSITION:
Each coted tablet contains : Levofloxacin 250mg, 500mg.
PROPERTIES:
Levofloxacin is a synthetic broad spectrum antibacterial agent, it is the L-isomer ofOfloxacin and considered to be twice as potent as floxacin
- it acts by inhibition of DNA gyrase (an enzyme required forDNA replication, transcription and repair.
Levofloxacin is rapidly and completely absorbed after oral administration, peak plasma concentration is usually attained one to two hours after oral dosing, it is excreted largely as unchanged drug in the urine. Levofloxacin is active against a wide range of gram-negative and gram-positive microorganisms such as : Streptococcus pneumoniae, Staphy-lococcus aureus,tscherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis and other microorganisms (Chlamydia pneumoniae, Mycoplasma pneumoniae ).
INDICATIONS:
Levotop is indicated for the treatment of adults with mild, moderate, and severe infections caused by susceptible microorganisms such as :
- Acute maxillary sinusitis
- Acute and chronic bronchitis
- Community - acquired pneumonia
- Uncomplicated skin and soft tissue (abscesses, furuncles, impetigo, wound infections)
- Complicated urinary tract infections
- Acute pyelonephritis
CONTRAINDICATIONS:
- Hypersensitivity to one of the components .
- Pregnancy and lactation
- Infants and children
SIDE EFFECTS:
Nausea, diarrhea, abdominal pain, dyspepsia, dizziness, headache, anxiety, fatigue, nervousness, pruritus, genital moniliasis and rarely abnormal renal function
PRECAUTIONS:
Adequate hydration of patients receiving Levotop should be maintained
Excessive exposure to sunlight should be avoided.
It should be used with caution in patients with renal insufficiency and
central nervous system disorder (epilepsy ) .
Periodic assessment of organ system functions, including renal, hepatic, and hematopoietic, is advisable during therapy .
DRUG INTERACTIONS:
Antacids, sucralfate, multivitamins, these agents should be taken at least two hours before or two hours after Levotop administration. Theophylline levels should be closely monitored and appropriate dosage adjustments made when Levotop is co-administered. The prothrombin time should be closely monitored if a Levotop is administered concomitantly with warfarin, concomitant ofanon-stero-idal anti-inflammatory with Levotop may increase the risk of CNS stimulation and convulsive seizures.
DOSAGE AND ADMINISTRATION:
Doses should be reduced in patients with renal insufficiency The usual dose of Levotop is 500mg every 24 hours Duration of treatment in patients with normal renal function :
Chronic bronchitis: 500mg daily for 7 days Comm. Acquired pneumonia: 500mg daily for 7 - 14 days Acute maxillary sinusitis : 500mg daily for 10 - 14 dayli Complicated urinary tract infection : 250mg daily forlU days Acute pyelonephritis : 250mg daily for 10 days
DOSAGE IN PATIENTS WITH IMPAIRED RENAL FUNCTION:
Clearance doses
From 50-80 ml / min no dosage adjustment required
From 20-49 ml / min 250mg every 24 hour
From 10-19 ml / min 250mg every 48 hour
Hemodialysis 250mg every 48 hour
PRESENTATION:
Box of 10 tablets 250mg. Box of 10 tablets 500mg. |
